The Upper Deschutes Headwaters section from Crane up to Little Lava is well worth the effort. A lot of nymph action and streamers are the flies to work with, but keep an eye out on a few hatches of midges, PMD’s and caddis.
A dry dropper with a Black Hippie Stomper and a Rainbow Warrior is a good combo to start with but nymphing a Walts Worm is my favorite. I like whitefish by the way!